The second season uses the exact same formula, except now we follow the heroine Ogiue Chika who absolutely despises Otakus even though it is obvious she is one. The rest of the cast now take on much more serious endeavors; as many of them are set to graduate, the job hunt is on. And they are not content with simply going to Comifes anymore, instead we follow them as they go through not one but two group publications. Every single detail is as true-to-life as it can be. Again, I don't want to spoil too much, but new relationships are also explored. The Kasukabe X Kousaka couple's limits are also pushed to new extremes; if you thought she had it bad in season 1, you've seen nothing.
The later episodes also introduce two new characters, Sue and Angela, two American Otakus who join Genshiken as guest members for a short time. Both of them were Ohno's friends when she lived in America and they showed up at the last minute for Comifes. Most of their manners are considered rude by the Genshiken crew but they try their best to accomodate them, as most Japanese people are wont to do. Note that every little bit of Engrish was spoken by Japanese VAs, so the end result is simply hilarious (the internet agrees). The writers definitely wanted to leave no stone unturned this season as yaoi manga is also explored in great detail.